{"created":"2023-05-15T13:30:05.425797+00:00","id":179,"links":{},"metadata":{"_buckets":{"deposit":"035456b2-9078-420c-83f4-326bc591bbe7"},"_deposit":{"created_by":5,"id":"179","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"179"},"status":"published"},"_oai":{"id":"oai:mfri.repo.nii.ac.jp:00000179","sets":["14:25"]},"author_link":["306","305"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"富士山研究"},{"bibliographic_title":"Mount Fuji Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The immune system, reacting to bacterial and viral infections, affects nervous and endocrine systems, and the nervous and endocrine systems, by responding to various stressors, then affect both humoral and cell-mediated immune response. Acute thermal stress increases the number of NK cells and T (CD8) cells, and reduce the number of T (CD4) cells. These changes are mainly mediated by β-actions of the sympathetic neurones. The secretion rate of salivary sIgA (sIgA), the predominant immunoglobulin in the mucosal immune system, is increased by acute cold stress probably via β-adrenoceptors. Properties of stressors and individual differences in the styles coping with stress infl uence the sIgA response to stress. Long-term exposure to thermal stress activates the hypothalamic-pituitary-adrenal axis, and suppresses immune activities. The phagocytotic activity of macrophages, the number and activity of NK cells, and the antibody production are inhibited by chronic thermal stress. The composition of T (CD4) cell subtypes is also infl uenced by chronic stress. The decrease in the ratio of Th1 cells to Th2 cells by chronic stress provides different patterns of cytokines released by these T cells and infl uence the immune activity. The dominance of Th1 or Th2 predicts the susceptibility of the hypothalamic-pituitary-adrenal axis to stressors in animal models. Heat shock proteins (HSPs) induced by heat exposure infl uence the expression of the T cell receptor (TCR) and the intracellular signalling in T cells. HSPs also block the transcription of TNF mRNA and decrease the production TNF by macrophages.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"富士山科学研究所"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-7564","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永井, 正則"},{"creatorName":"ナガイ, マサノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"305","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAGAI, Masanori ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"306","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-22"}],"displaytype":"detail","filename":"MFR_No06_p1_p8.pdf","filesize":[{"value":"676.7 kB"}],"format":"application/pdf","license_note":"Copyright (c) Mount Fuji Research Institute, Yamanashi Prefectural Government.\n","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"富士山研究　第6巻1～8頁","url":"https://mfri.repo.nii.ac.jp/record/179/files/MFR_No06_p1_p8.pdf"},"version_id":"d9209690-f3ee-4c18-9201-2057638d95a7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sIgA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Heat shock proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Systemic immune system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mucus immune system","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"温度ストレスが免疫機能に与える影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"温度ストレスが免疫機能に与える影響"},{"subitem_title":"CHANGES IN IMMUNE ACTIVITIIES BY THERMAL STRESS ― An Overview of Findings in the 1980’s and 1990’s ―","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["25"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-22"},"publish_date":"2022-03-22","publish_status":"0","recid":"179","relation_version_is_last":true,"title":["温度ストレスが免疫機能に与える影響"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-05-15T13:37:03.500938+00:00"}